I have fairly small calves, but I think these socks would not be too tight for the average leg. They are thick and warm, and somewhat padded in the right places for ski boots. I don't think the toe seam would be a problem either.
Good question! These socks are a bit tight in the leg particularly at the top hem (I'm a thin person). The toe hem isn't too thick or bulky. Ironically, I'm a nurse and I wouldn't recommend these socks for the condition you describe. I wish you well in your treatment!